We are currently performing the same exercise (Well I'm going to keep my local copy as I like to fiddle about and try new plug ins!)
No major issues so far - I have had sporadic reports of memory errors which occasionally have required users to be forced off, but I think that is due to users...
I understand that there is an overhead in compiling with debug info turned on?
I have just realised that we have been using PL Developer to compile packages in our production database with the option turned on! (Maybe the default should be that the option is turned off in preferences?)
How...