Even on Apple Silicon (M1, M2, M3) you can use the
Intel version of the Oracle Instant Client. Plyxon will use this Oracle Client version. Apple Silicon can run Intel code, so this all works fine.
At the moment there is indeed no Oracle Client available for Apple Silicon. There is only an Intel version for macOS. As soon as Oracle releases an Instant Client for Apple Silicon, we will make a Plyxon version for Apple Silicon as well.